Poor sleep may bolster genetic susceptibility to asthma risk | BMJ
Primatene Tablets
Primatene Tablets Generic Name & Formulations General DescriptionEphedrine HCl 12.5mg.
Pharmacological ClassSympathomimetic.
How SuppliedTabs—24, 60
How SuppliedPrimatene Tablets are supplied as: packs of 24 packs of 60
StorageStore at 20-25°C (68-77°F).
Primatene Tablets Indications IndicationsTemporary relief of mild symptoms of intermittent asthma (eg, wheezing, tightness of chest, shortness of breath).
Primatene Tablets Dosage and Administration AdultDo not exceed recommended dose. 1–2 tabs every 4 hours as needed. Max: 12 tabs per 24 hours.
Children<12yrs: not recommended.
Primatene Tablets Contraindications ContraindicationsDuring or within 14 days of MAOIs.
ContraindicationsIf currently taking a prescription monoamine oxidase inhibitor (MAOI) (eg, certain drugs taken for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug.History of an allergic reaction to this product or any of its ingredients.
Primatene Tablets Boxed WarningsNot Applicable
Primatene Tablets Warnings/Precautions Warnings/PrecautionsAsthma associated hospitalization. Cardiac disease. Hypertension. Diabetes. Thyroid disease. Seizures. Narrow angle glaucoma. Psychoses. Difficulties urinating. Enlarged prostate gland. Seek medical evaluation if symptoms worsen or do not improve within 60mins, or need 12 tabs in any day, or use >8 tabs/day for 3 or more days a week, or have >2 asthma attacks/week. Pregnancy. Nursing mothers.
Warnings/PrecautionsPrimatene tablets will not give you asthma relief as quickly as an inhaled bronchodilator.
Pregnancy ConsiderationsConsult a health provider prior to use.
Nursing Mother ConsiderationsConsult a health provider prior to use.
Primatene Tablets PharmacokineticsSee Literature
Primatene Tablets Interactions InteractionsAvoid caffeine-containing products, stimulant dietary supplements. Caution with other sympathomimetics (eg, phenylephrine, pseudoephedrine, ephedrine), antiasthmatics, weight control agents, antidepressants, antipsychotics, sedatives.
Primatene Tablets Adverse Reactions Adverse ReactionsInsomnia, tachycardia, tremors, nervousness, seizures.
Primatene Tablets Clinical TrialsSee Literature
Primatene Tablets NoteNot Applicable
Primatene Tablets Patient Counseling Patient CounselingKeep out of reach of children. In case of overdose, get medical help. Contact a Poison Control Center right away.
Primatene Mist HFA Aerosol With Adapter
Headache, nausea, vomiting, nervousness, dizziness, shaking (tremor), trouble sleeping, stomach upset, sweating, dry mouth, bad taste, cough, or sore throat may occur. If any of these effects last or get worse, notify your doctor or pharmacist promptly.
If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.
Tell your doctor right away if you have any serious side effects, including: fast/pounding/irregular heartbeat, muscle cramps, weakness, mental/mood changes (such as anxiety, hallucinations).
Get medical help right away if you have any very serious side effects, including: chest pain.
Rarely, this medication has caused severe (rarely fatal), sudden worsening of breathing problems/asthma (paradoxical bronchospasm). If you experience sudden wheezing, get medical help right away.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.Fda.Gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
1997 Pontiac Hurst Firebird By Lingenfelter Is As Good As Gold
From the November 1997 issue of Car and Driver.
George Hurst's first customized shifter was for a 1956 Chevy. It had shorter throws from gear to gear and a more precise feel than stock shifters. In no time, performance drivers everywhere were lining up for them. Detroit automakers were serious about performance back then, and by the Sixties, a Hurst shifter could be ordered on many cars—even Buicks!
In 1968, Hurst went beyond just turning out shifters. He built an Oldsmobile Cutlass 442 with a huge Toronado 455-cubic-inch V-8 under the hood. In addition to all that horsepresssure, this Hurst car stressed speed and comfort—something traditionally absent in most muscle cars of the day. Moreover, at the time, GM had a ban on engines larger than 400 cubic inches from all but the largest models. Oldsmobile may have seen the Hurst car as one way to get around GM's policy and keep one serious racehorse in the stable by producing regular Cutlass 442s and then having Hurst perform the engine swap after the cars left the factory.
Since 1968, nine Oldsmobiles and three American Motors cars have carried Hurst badging. The latest Hurst car, a modified 1997 Pontiac Firebird Trans Am WS6, developed in a roundabout way. Hurst, now owned by Mr. Gasket, the performance-parts company, borrowed a car from Pontiac to develop a shifter for the Firebird's automatic transmission.
Pontiac PR man Mark Hitchins handed over a black WS6 and suggested that maybe it was time for another Hurst car. Hurst agreed. Since both Pontiac and Hurst wanted the car to be more than just a paint-and-trim package, they called well-known aftermarket tuner John Lingenfelter. The result is not just a Hurst Firebird—it's a Hurst Firebird by Lingenfelter.
Lingenfelter's goal was to increase horsepower without jacking up the price too severely. The LT1 engine in a stock 1997 WS6 Firebird with a ram-air intake system makes 305 hp; Lingenfelter wanted to kick that up to 350.
Just as Primatene Mist opens up clogged breathing passages, Lingenfelter uncorked the LT1. First, he ported a set of cylinder heads and an intake manifold from the now defunct Corvette Grand Sport's LT4 engine and installed them. Next came stronger valve springs and pushrods with titanium retainers (these helped allow the redline to increase by 800 revs). Longer roller rocker arms and a Lingenfelter Performance Engineering (LPE) custom-ground camshaft provided higher lift and more duration.
On the exhaust side, Lingenfelter installed new headers and added a Borla stainless-steel exhaust system. To handle the increased power, he specified an aluminum driveshaft 3.5 inches in diameter and, for more traction, swapped the original Goodyear rubber for Michelin Pilot SX tires, in the same size.
Of course, the Hurst six-speed shifter, with its well-established short throws and precise feel, was also added.
A Hurst custom job also includes a dose of body cha-cha. A ground-effects package complements the lower body panels, although WS6 Firebirds are already so busy-bodied that it's tough to notice the new zoot. There is, however, no missing the car's trick paint job, with gold aluminum wheels and gold paint covering the decklid and the hood.
The car is loaded with options. There's a T-top, power leather seats (they bear badges that say "Hurst Firebird by Lingenfelter"), a CD and cassette player, cruise control, and power for the mirrors, windows, and locks.
More on the Pontiac FirebirdWe like the extra options, but let's face it: This car is about extra speed. At the track, the 15-percent increase in horsepower pays off. The 0-to-60 routine takes 4.7 seconds, which is 0.6 second quicker than the new LS1-powered '98 Trans Am. The quarter-mile flashes by in just 13.1 seconds at 111 mph. That makes this Hurst car the quickest set of wheels in the GM stable—outrunning even the new Corvette. (The fastest new Vette we've tested hit 60 mph in 4.8 seconds and ran the quarter-mile in 13.3 seconds at 109 mph.) The Hurst Firebird is still ahead of the Vette at 150 mph, and it stays there to a whopping terminal velocity of 182 mph, 23 mph faster than the new Trans Am and 7 mph faster than the Vette. Given the Vette's 345 horsepower rating—that's five less than this Hurst car—we think Lingenfelter's estimate of 350 horses is, as even he says, "conservatively low."
Oh, did we mention that the Hurst car generates 0.89 g on the skidpad, which is an improvement of 0.04 over the stock version? Did we mention there is no free lunch? In 1968, a Hurst package added $400 to the model. Today, it adds $15,495. Tack that onto an already pricey $28,789 WS6 Firebird, and you have—cha-ching!—a payment schedule involving $44,947.
Well, think of this car as the most exclusive ride this side of a Ferrari F50. That's because only nine of these Hurst Firebirds by Lingenfelter (designated as 1997 models) will make it into customers' hands. Why so few? The original plan called for 50 cars, but by the time contractual details were finalized, only nine WS6 cars, of 3807 built, had yet to be sold. Pontiac and Lingenfelter haven't inked a deal yet for a Hurst version of the new LS1-powered Firebird, but chances are good they will. Either way, if you were one of the lucky souls to get your hands on a 1997 model, hang on to it. Who knows? Twenty years from now, it just might be worth some serious cash.
Arrow pointing down SpecificationsSpecifications
1997 Pontiac Hurst Firebird by LingenfelterVehicle Type: front-engine, rear-wheel-drive, 2+2-passenger, 2-door coupe
PRICE Base/As Tested: $21,249/$44,947Options: Hurst package (LPE 350-hp engine package, ground effects, Hurst shifter, aluminum driveshaft, gold graphics, car cover, gold aluminum wheels, Michelin Pilot SX 275/40ZR-17 tires, oil cooler, embroidered floor mats and headrests, numbered dash plaque, and key chain), $15,495; WS6 option package (ram-air induction system, air scoops, dual polished exhaust outlets, performance suspension), $3345; 1SB option package (power locks, windows, and mirrors; cruise control; rear-window defroster), $1121; T-tops, $995; leather seats, $829; remote CD changer, $595; steering-wheel radio controls, $200; keyless entry, $150; Delco stereo, $130; theft alarm, $90; power antenna, $85; luxury tax on options, $663
ENGINEpushrod V-8, iron block and aluminum heads, port fuel injectionDisplacement: 350 in3, 5733 cm3Power: 350 hp @ 6000 rpmTorque: 375 lb-ft @ 4500 rpm
TRANSMISSION6-speed manual
CHASSIS Suspension, F/R: control arms/live axleBrakes, F/R: 10.7-in vented disc/11.4-in vented discTires: Michelin Pilot SX275/40ZR-17
DIMENSIONS Wheelbase: 101.1 inLength: 197.0 inWidth: 74.5 inHeight: 52.0 inPassenger Volume, F/R: 53/31 ft3Trunk Volume: 13 ft3Curb Weight: 3554 lb
C/D TEST RESULTS 60 mph: 4.7 sec100 mph: 10.9 sec1/4-Mile: 13.1 sec @ 111 mph130 mph: 18.8 sec150 mph: 30.6 secRolling Start, 5–60 mph: 5.6 secTop Gear, 30–50 mph: 14.0 secTop Gear, 50–70 mph: 13.5 secTop Speed (drag ltd): 182 mphBraking, 70–0 mph: 176 ftRoadholding, 300-ft Skidpad: 0.89 g
C/D TESTING EXPLAINED
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